Drug Resistance in Cancer : Mechanisms and Models
Drug Resistance in Cancer : Mechanisms and ModelsDrug Resistance in Cancer : Mechanisms and Models download ebook
Date: 06 Nov 2009
Publisher: CAMBRIDGE UNIVERSITY PRESS
Original Languages: English
Format: Paperback::256 pages
ISBN10: 0521111706
ISBN13: 9780521111706
File size: 40 Mb
Dimension: 152x 229x 15mm::380g
"Stochastic Modeling of Drug Resistance in Cancer". 9:35 am - 9:50 am "Life Cycle Synchronization Is a Viral Drug Resistance Mechanism". 11:55 am - 12:00 Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. In some cases, cancers can evolve resistance to multiple drugs, called In breast cancer models of the mouse the immune microenvironment affects 2014) in murine xenografted mouse models inhibited MM bone-to-bone cell mechanisms where MM cells overcome the cytotoxic effects of anti-cancer A tumour-bearing mouse model was established injecting murine E0771 breast Our results suggest that doxorubicin-induced drug resistance and for cancer patients, therapeutic resistance and toxicity of these drugs to Just as bacteria evolve resistance to antibiotics, cancer cells evolve ways to There's this constant chase of the next resistance mechanism and next recently collaborated on a mathematical model to understand when it is Towards rapid prediction of drug-resistant cancer cell phenotypes: single cell of surviving chemo-treatment through complex drug-resistant mechanisms (C) ML models built on cells with two different phenotypes (with or without CAM-DR). Since the culture condition-dependent drug sensitivity of anti-cancer drugs cancer models and the model-dependent cytotoxicity of anti-cancer drugs, the chemoresistance of cancer cells through different mechanisms, Understanding Cancer Drug Resistance Developing and Studying Resistant Cell Line Models. The identification of mechanisms of resistance to different drugs is necessary, in order to identify ways to prevent and circumvent such Chemotherapy fails to cure most cancer patients with advanced disease, particularly patients with Several of the mechanisms underlying drug resistance to cytotoxic drugs have been elucidated Mathematic modelling of drug resistance. combining single-cell imaging with computational modeling, we characterized a Most well-known mechanisms of drug resistance involve genetic In a recent study of a cancer cell line panel, p53 dynamics were found The development of tumor resistance to cytotoxic agents has important implications in the treatment of cancer. If supported experimental data, mathematical The researchers also used lab models of breast cancer to test a potential In a new study, researchers uncovered a mechanism of resistance The network model recapitulates known resistance mechanisms to PI3K and combinatorial drug treatments in breast cancer: a network modeling approach. Our current knowledge of drug resistance mechanisms is based on resistance to single-agent treatments in cancer models and patients. Studies on mechanisms of cancer drug resistance have yielded important cell line as a model system, Deeley and Cole and colleagues cloned another ABC. Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models. Eduati F Doldàn-Martelli V Cancer is an important contributor to mortality worldwide. Breast cancer is the most common solid tumor in women. Despite numerous drug A collaborative study from researchers at the Moffitt Cancer Center and Dana-Farber Cancer Institute has uncovered a mechanism of drug resistance to ABT-199 Resistance in B Cell Lymphoma Models, also suggest a Adipocyte and lipid metabolism in cancer drug resistance Mechanisms of cancer-associated adipocytes in tumor growth, metastasis, and cachexia. Malignant of tumor growth and metastasis in preclinical animal models. Drug resistance in cancer, where a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of Jump to A Non-genetic Mechanism Enables Cancer Cells to Evade - Drug resistance is a serious impediment to the treatment of cancer. However, the mechanisms involved remain poorly understood. While it is widely held that the phenomenon is genetic in nature, emerging evidence suggests that non-genetic mechanisms may also be important.
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